| Feb 1-20 | Salary arbitration hearings, St. Petersburg, FL. |
| Feb 16 | Voluntary reporting date for pitchers, catchers, and injured players. |
| Feb 21 | Voluntary reporting date for other players. |
| Feb 27 | Hall of Fame Negro leagues and pre-Negro league selection committee vote, Tampa, FL. |
| Feb 28 | Mandatory reporting date for all players. |
| Mar 2-11 | Teams may renew contracts of unsigned players. |
| Mar 3-20 | World Baseball Classic. |
| Mar 15 | Last day to place a player on unconditional release waivers and pay 30 days termination pay instead of 45 days. |
| Mar 29 | Last day to request unconditional release waivers on a player without having to pay his full 2006 salary. |
| Apr 2 | Opening Day, Cleveland Indians at Chicago White Sox. Active rosters reduced to 25 players. |
| May 15 | Hall of Fame Game, Cincinnati Reds vs. Pittsburgh Pirates, Cooperstown, NY. |
| Jun 6-7 | Amateur draft. |
| Jul 11 | All-Star Game, Pittsburgh. |
| Jul 30 | Hall of Fame inductions, Cooperstown, NY. |
| Jul 31 | Last day to trade a player without securing waivers. |
| Sep 1 | Active rosters expand to 40 players. |
| Oct 3 | Playoffs begin. |
| Oct 10 | League Championship Series begin. |
| Oct 21 | World Series begins. |
| Oct 26? | Free agent filing period, first 15 days after World Series ends. |
| Nov 13-17 | General managers' meetings, Naples, FL. |
| Dec 4-7 | Winter meetings, Lake Buena Vista, FL. |
| Dec 4-8 | Major League Baseball Players Association executive board meeting, Bonita Springs, FL. |
| Dec 7 | Last day for teams to offer salary arbitration to their players who became free agents. |
| Dec 19 | Last day for free agents offered salary arbitration to accept or reject the offers. |
| Dec 20 | Last day for teams to offer 2007 contracts to unsigned players. |
| |
| 2007 |
| Jan 5-15 | Salary arbitration filing. |
| Jan 8 | Last day until May 1 for free agents who rejected arbitration offers to re-sign with their former teams. |
| Jan 18 | Exchange of salary arbitration figures. |
| Feb 1-21 | Salary arbitration hearings. |